Tips for understanding Non-inferiority Trials

Format: Norsk
Language/s: 3-4 - How certain is the evidence?
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Short Description:

A non-inferiority experiment endeavours to show that a new intervention is ‘not unacceptably worse’ than the comparison intervention.

Key Concepts addressed:


“Trials to show superiority generally penalize the sloppy investigator (although not always; improper handling of missing data can benefit a more toxic, less efficacious treatment, potentially increasing the possibility of a false finding in a superiority trial). By contrast, non-inferiority trials tend to reward the careless. The less rigorously conducted the trial, the easier it can be to show non-inferiority.” From an article in the journal, Trials, entitled, “Through the looking glass: understanding non-inferiority.”

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